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1

High affinity IgM+ memory B cells are generated through a germinal center-dependent pathway

Hara, Yasushi, Tashiro, Yasuyuki, Murakami, Akikazu, Nishimura, Miyuki, Shimizu, Takeyuki, Kubo, Masato, Burrows, Peter D., Azuma, Takachika

Journal:

Molecular Immunology

Year:

2015

Language:

english

File:

PDF, 1.78 MB

english, 2015

2

Ionization and Reactivities of the Thiol Groups Which Participate in the Formation of Interchain Disulfide Bonds of Bence Jones Proteins and an Fab(t) Fragment1

TANAKA, Yoko, AZUMA, Takachika, HAMAGUCHI, Kozo

Journal:

Journal of Biochemistry

Year:

1978

Language:

english

File:

PDF, 901 KB

english, 1978

3

High-affinity IgM+ memory B cells are defective in differentiation into IgM antibody-secreting cells by re-stimulation with a T cell-dependent antigen

Tashiro, Yasuyuki, Murakami, Akikazu, Hara, Yasushi, Shimizu, Takeyuki, Kubo, Masato, Goitsuka, Ryo, Kishimoto, Hidehiro, Azuma, Takachika

Journal:

Scientific Reports

Year:

2018

Language:

english

File:

PDF, 1.68 MB

english, 2018

4

Quantitation of anti-NP (4-hydroxy-3-nitrophenyl)-acetyl idiotype expression on spleen and thymus cells

Katherine A. Wall, A. Raymond Frackelton Jr., Edward B. Reilly, Takachika Azuma, Tse-Wen Chang, Herman N. Eisen

Journal:

European Journal of Immunology

Year:

1983

Language:

english

File:

PDF, 906 KB

english, 1983

5

Bispecific F(ab′)2 monomer prepared with anti-CD3 and anti-tumor monoclonal antibodies is most potent in induction of cytolysis of human T cells

Taizo Nitta, Hideo Yagita, Takachika Azuma, Kiyoshi Sato, Ko Okumura

Journal:

European Journal of Immunology

Year:

1989

Language:

english

File:

PDF, 691 KB

english, 1989

6

Accumulation of somatic hypermutation and antigen-driven selection in rapidly cycling surface Ig+ germinal center (GC) B cells which occupy GC at a high frequency during the primary antihapten response in mice

Hiroshi Kimoto, Hitoshi Nagaoka, Yoshihiro Adachi, Toshiaki Mizuochi, Takachika Azuma, Takenori Yagi, Tetsutaro Sata, Shin Yonehara, Yasuko Tsunetsugu-Yokota, Masaru Taniguchi, Toshitada Takemori

Journal:

European Journal of Immunology

Year:

1997

Language:

english

File:

PDF, 3.45 MB

english, 1997

7

DNA polymerase η is a limiting factor for A:T mutations in Ig genes and contributes to antibody affinity maturation

Keiji Masuda, Rika Ouchida, Masayuki Yokoi, Fumio Hanaoka, Takachika Azuma, Ji-Yang Wang

Journal:

European Journal of Immunology

Year:

2008

Language:

english

File:

PDF, 178 KB

english, 2008

8

Specific cytolysis of HIV-infected cells by lymphocytes armed with bifunctional antibodies

Hidechika Okada, Hiroshi Momota, Takachika Azuma, Toshio Hattori, Noriko Okada

Journal:

Immunology Letters

Year:

1992

Language:

english

File:

PDF, 402 KB

english, 1992

9

Elimination of HIV-infected cells by lymphocytes armed with a bifunctional antibody to gp120 of HIV and CD3

Hidechika Okada, Hiroshi Momota, Noriko Okada, Takashi Okamoto, Takachika Azuma

Journal:

Immunology Letters

Year:

1993

Language:

english

File:

PDF, 477 KB

english, 1993

10

Molecular characterization of monovalent and multivalent hapten–protein conjugates for analysis of the antigen–antibody interaction

Masayuki Oda, Naoko Sato-Nakamura, Takachika Azuma

Journal:

Analytical Biochemistry

Year:

2004

Language:

english

File:

PDF, 767 KB

english, 2004

11

Molecular basis of antigen recognition by insulin specific T cell receptor

Shigeru Sugiyama, Masako Kohyama, Masayuki Oda, Takachika Azuma, Joan E Wither, Nobumichi Hozumi

Journal:

Immunology Letters

Year:

2004

Language:

english

File:

PDF, 139 KB

english, 2004

12

Normal immunoglobulin gene somatic hypermutation in Polκ–Polι double-deficient mice

Takeyuki Shimizu, Takachika Azuma, Mariko Ishiguro, Naoko Kanjo, Shuichi Yamada, Haruo Ohmori

Journal:

Immunology Letters

Year:

2005

Language:

english

File:

PDF, 113 KB

english, 2005

13

A role for the P1 anchor residue in the thermal stability of MHC class II molecule I-Ab

Toranosuke Tobita, Masayuki Oda, Hisayuki Morii, Masataka Kuroda, Atsuko Yoshino, Takachika Azuma, Haruo Kozono

Journal:

Immunology Letters

Year:

2003

Language:

english

File:

PDF, 384 KB

english, 2003

14

Identification of a novel plant MAR DNA binding protein localized on chromosomal surfaces

Satoru Fujimoto, Sachihiro Matsunaga, Masataka Yonemura, Susumu Uchiyama, Takachika Azuma, Kiichi Fukui

Journal:

Plant Molecular Biology

Year:

2004

Language:

english

File:

PDF, 1.08 MB

english, 2004

15

The absence of DNA polymerase κ does not affect somatic hypermutation of the mouse immunoglobulin heavy chain gene

Takeyuki Shimizu, Yoichi Shinkai, Tomoo Ogi, Haruo Ohmori, Takachika Azuma

Journal:

Immunology Letters

Year:

2003

Language:

english

File:

PDF, 246 KB

english, 2003

16

In vitro Anti-tumor Activity of Anti-c-erbB-2 × Anti-CD3ɛ Bifunctional Monoclonal Antibody

Yoshihiro Sugiyama, Miki Aihara, Masafumi Shibamori, Kyohei Deguchi, Kenichi Imagawa, Mikio Kikuchi, Hiroshi Momota, Takachika Azuma, Hidechika Okada, Özge Alper, Jiro Hitomi, Ken Yamaguchi

Journal:

Year:

1992

File:

PDF, 283 KB

1992

17

Somatic hypermutation in mouse λ chains

Takachika Azuma

Journal:

Immunological Reviews

Year:

1998

Language:

english

File:

PDF, 4.00 MB

english, 1998

18

Regional and segmental flexibility of antibodies in interaction with antigens of different size

Masayuki Oda, Susumu Uchiyama, Carol V. Robinson, Kiichi Fukui, Yuji Kobayashi, Takachika Azuma

Journal:

Year:

2006

Language:

english

File:

PDF, 694 KB

english, 2006

19

PHB2 Protects Sister-Chromatid Cohesion in Mitosis

Hideaki Takata, Sachihiro Matsunaga, Akihiro Morimoto, Nan Ma, Daisuke Kurihara, Rika Ono-Maniwa, Masatoshi Nakagawa, Takachika Azuma, Susumu Uchiyama, Kiichi Fukui

Journal:

Current Biology

Year:

2007

Language:

english

File:

PDF, 778 KB

english, 2007

20

The amino acid residue at position 95 and the third CDR region in the H chain determine the ceiling affinity and the maturation pathway of an anti-(4-hydroxy-3-nitrophenyl)acetyl antibody

Akikazu Murakami, Yuka Takahashi, Miyuki Nishimura, Takeyuki Shimizu, Takachika Azuma

Journal:

Molecular Immunology

Year:

2010

Language:

english

File:

PDF, 685 KB

english, 2010

21

Estimation of the relative affinity of B cell receptor by flow cytometry

Takeyuki Shimizu, Masayuki Oda, Takachika Azuma

Journal:

Journal of Immunological Methods

Year:

2003

Language:

english

File:

PDF, 324 KB

english, 2003

22

Human Pregnancy Serum Suppresses the Proliferative Response of Lymphocytes to Autologous PHA-Activated T Lymphoblasts

Ronit Wolf-Levin, Koji Aoki, Takachika Azuma, Yoshiaki Yagami, Hidechika Okada

Journal:

American Journal of Reproductive Immunology

Year:

1996

Language:

english

File:

PDF, 620 KB

english, 1996

23

Evaluation of the conformational equilibrium of reduced hen egg lysozyme by antibodies to the native form

Masayuki Oda, Aki Kitai, Akikazu Murakami, Miyuki Nishimura, Takatoshi Ohkuri, Yoshito Abe, Tadashi Ueda, Haruki Nakamura, Takachika Azuma

Journal:

Archives of Biochemistry and Biophysics

Year:

2010

Language:

english

File:

PDF, 757 KB

english, 2010

24

A landscape for the dynamics of an immune response

Atsuko Furukawa, Koji Furukawa, Takachika Azuma

Journal:

Biochemical and Biophysical Research Communications

Year:

2004

Language:

english

File:

PDF, 320 KB

english, 2004

25

Dynamical regulations of protein–ligand bindings at single molecular level

Takuma Sagawa, Takachika Azuma, Yuji C. Sasaki

Journal:

Biochemical and Biophysical Research Communications

Year:

2007

Language:

english

File:

PDF, 376 KB

english, 2007

26

RBMX: A Regulator for Maintenance and Centromeric Protection of Sister Chromatid Cohesion

Sachihiro Matsunaga, Hideaki Takata, Akihiro Morimoto, Kayoko Hayashihara, Tsunehito Higashi, Kouhei Akatsuchi, Eri Mizusawa, Mariko Yamakawa, Mamoru Ashida, Tomoko M. Matsunaga, Takachika Azuma, Susu

Journal:

Year:

2012

Language:

english

File:

PDF, 1.36 MB

english, 2012

27

Segmental flexibility and avidity of IgM in the interaction of polyvalent antigens

Toranosuke Tobita, Masayuki Oda, Takachika Azuma

Journal:

Molecular Immunology

Year:

2004

Language:

english

File:

PDF, 149 KB

english, 2004

28

Conformational changes in the antibody constant domains upon hapten-binding

Takuma Sagawa, Masayuki Oda, Hisayuki Morii, Hisao Takizawa, Haruo Kozono, Takachika Azuma

Journal:

Molecular Immunology

Year:

2005

Language:

english

File:

PDF, 281 KB

english, 2005

29

Initial repertoire of anti-(4-hydroxy-3-nitrophenylacetyl) antibodies as potential donors for effective affinity maturation

Koji Furukawa, Akio Manabe, Atsuko Furukawa, Hiroyoshi Kuba, Toshihide Okajima, Takachika Azuma

Journal:

Molecular Immunology

Year:

2006

Language:

english

File:

PDF, 422 KB

english, 2006

30

Strategy for affinity maturation of an antibody with high evolvability to (4-hydroxy-3-nitrophenyl) acetyl hapten

Koji Furukawa, Takeyuki Shimizu, Akikazu Murakami, Ryo Kono, Masatoshi Nakagawa, Takuma Sagawa, Ichiro Yamato, Takachika Azuma

Journal:

Molecular Immunology

Year:

2007

Language:

english

File:

PDF, 982 KB

english, 2007

31

Effects of antibody affinity and antigen valence on molecular forms of immune complexes

Masayuki Oda, Susumu Uchiyama, Masanori Noda, Yoshinori Nishi, Maiko Koga, Kouta Mayanagi, Carol V. Robinson, Kiichi Fukui, Yuji Kobayashi, Kosuke Morikawa, Takachika Azuma

Journal:

Molecular Immunology

Year:

2009

Language:

english

File:

PDF, 1.02 MB

english, 2009

32

Reevaluation of stoichiometry and affinity/avidity in interactions between anti-hapten antibodies and mono- or multi-valent antigens

Masayuki Oda, Takachika Azuma

Journal:

Molecular Immunology

Year:

2000

Language:

english

File:

PDF, 206 KB

english, 2000

33

Thermodynamic and kinetic aspects of antibody evolution during the immune response to hapten

Takuma Sagawa, Masayuki Oda, Miyuki Ishimura, Koji Furukawa, Takachika Azuma

Journal:

Molecular Immunology

Year:

2003

Language:

english

File:

PDF, 165 KB

english, 2003

34

Junctional Amino Acids Determine the Maturation Pathway of an Antibody

Koji Furukawa, Atsuko Akasako-Furukawa, Hiroki Shirai, Haruki Nakamura, Takachika Azuma

Journal:

Year:

1999

Language:

english

File:

PDF, 346 KB

english, 1999

35

Kinetics of inter-heavy chain disulfide bond formation of liganded and unliganded human immunoglobulin G by radioimmunoassay

Azuma Takachika, Takeda Junji, Motoyama Noboru, Okada Hidechika

Journal:

Molecular Immunology

Year:

1992

Language:

english

File:

PDF, 1.03 MB

english, 1992

36

Generation of monoclonal antibodies against chromosomal antigens that have a high sequence similarity between human and mouse

Tsunehito Higashi, Shuichi Miyakawa, Susumu Uchiyama, Sachihiro Matsunaga, Hideaki Takata, Satoru Fujimoto, Masanori Noda, Akiko Terauchi, Takeyuki Shimizu, Masayuki Oda, Takachika Azuma, Kiichi Fukui

Journal:

Journal of Biotechnology

Year:

2005

Language:

english

File:

PDF, 545 KB

english, 2005

37

Maturation of the immune response to (4-hydroxy-3-nitrophenyl)-acetyl (NP) haptens in C57BL/6 mice

Azuma Takachika, Sakato Nobuo, Fujio Hajime

Journal:

Molecular Immunology

Year:

1987

Language:

english

File:

PDF, 1.28 MB

english, 1987

38

Transmission Electron Microscopy Observation of Antibody

Marina Kamogawa, Junichi Shimanuki, Takachika Azuma, Akikazu Murakami, Takashi Ishiguro

Journal:

Procedia Engineering

Year:

2012

Language:

english

File:

PDF, 358 KB

english, 2012

39

In-vitro derived germinal centre B cells differentially generate memory B or plasma cells in vivo

Nojima, Takuya, Haniuda, Kei, Moutai, Tatsuya, Matsudaira, Moeko, Mizokawa, Sho, Shiratori, Ikuo, Azuma, Takachika, Kitamura, Daisuke

Journal:

Nature Communications

Year:

2011

Language:

english

File:

PDF, 2.39 MB

english, 2011

40

Highly robust protein production by co-culture of CHO spheroids layered on feeder cells in serum-free medium

Kutsuzawa, Koichi, Suzuki, Toshihiro, Kishimoto, Hidehiro, Murakami, Akiichi, Azuma, Takachika, Abe, Ryo, Otsuka, Hidenori

Journal:

Colloid & Polymer Science

Year:

2014

Language:

english

File:

PDF, 778 KB

english, 2014

41

Chronic inflammation of the skin can be induced in IgE transgenic mice by means of a single challenge of multivalent antigen

Sato, Eiichiro, Hirahara, Kazuki, Wada, Yoshihiro, Yoshitomi, Tomomi, Azuma, Takachika, Matsuoka, Kunie, Kubo, Shuichi, Taya, Choji, Yonekawa, Hiromichi, Karasuyama, Hajime, Shiraishi, Akio

Journal:

Journal of Allergy and Clinical Immunology

Year:

2003

Language:

english

File:

PDF, 1.10 MB

english, 2003

42

[Part 2: Biological Sciences] || Identification of a Third Type of λ Light Chain in Mouse Immunoglobulins

Takachika Azuma, Lisa A. Steiner and Herman N. Eisen

Journal:

Proceedings of the National Academy of Sciences

Year:

1981

Language:

english

File:

PDF, 1.23 MB

english, 1981

43

[Part 1: Biological Sciences] || A Small Hypervariable Segment in the Variable Domain of an Immunoglobulin Light Chain Stimulates Formation of Anti-Idiotypic Suppressor T Cells

Nobuo Sakato, Masanori Semma, Herman N. Eisen and Takachika Azuma

Journal:

Proceedings of the National Academy of Sciences

Year:

1982

Language:

english

File:

PDF, 820 KB

english, 1982

44

[Part 1: Biological Sciences] || Diversity at the Variable-Joining Region Boundary of λ Light Chains Has a Pronounced Effect on Immunoglobulin Ligand-Binding Activity

Takachika Azuma, Vivien Igras, Edward B. Reilly and Herman N. Eisen

Journal:

Proceedings of the National Academy of Sciences

Year:

1984

Language:

english

File:

PDF, 899 KB

english, 1984

45

Characterization of the combining site of mouse myeloma protein M315

Azuma, Takachika, Sakato, Nobuo, Fujio, Hajime

Journal:

Year:

1988

Language:

english

File:

PDF, 619 KB

english, 1988

46

Bound Peptide-Dependent Thermal Stability of Major Histocompatibility Complex Class II Molecule I-E k†

Saito, Keigo, Oda, Masayuki, Sarai, Akinori, Azuma, Takachika, Kozono, Haruo

Journal:

Year:

2004

Language:

english

File:

PDF, 100 KB

english, 2004

47

Contribution of a Single Hydrogen Bond between βHis81 of MHC Class II I-E k and the Bound Peptide to the pH-Dependent Thermal Stability

Saito, Keigo, Oda, Masayuki, Sarai, Akinori, Azuma, Takachika, Kozono, Haruo

Journal:

Microbiology and Immunology

Year:

2004

Language:

english

File:

PDF, 199 KB

english, 2004

48

Detection and isolation of anti-hapten antibody-secreting cells by cellular affinity matrix technology

Shimizu, Takeyuki, Azuma, Takachika

Journal:

Journal of Immunological Methods

Year:

2015

Language:

english

File:

PDF, 878 KB

english, 2015

49

Mutations of the chloramphenicol acetyl transferase transgene driven by the immunoglobulin promoter and intron enhancer

Azuma, Takachika, Motoyama, Noboru, Fields, Larry E., Loh, Dennis Y.

Journal:

International Immunology

Year:

1993

Language:

english

File:

PDF, 6.67 MB

english, 1993

50

An asymmetric antibody repertoire is shaped between plasmablasts and plasma cells after secondary immunization with (4-hydroxy-3-nitrophenyl)acetyl chicken γ-globulin

Tashiro, Yasuyuki, Murakami, Akikazu, Goizuka, Ryo, Shimizu, Takeyuki, Kishimoto, Hidehiro, Azuma, Takachika

Journal:

International Immunology

Year:

2015

Language:

english

File:

PDF, 870 KB

english, 2015